My Sunday group playtested Scion: Hero last night. I don't know if White Wolf will enter it or not, but I know they entered (and won with) at least one product last year, so I figured there was at least a reasonable chance.
All in all we loved it. I was pretty shocked at the number of dice we rolled, and I run a regular Shadowrun game, so that's saying something. It wasn't uncommon to see players having to roll two or three handfuls of dice when making an attack. Not that it's necessarily a bad thing, but I could see where it might turn some people off.
Other than that I don't think we had any problems with the system. It was quick, and we had no problem teaching four players who had never even seen the book everything they needed to know in about a half-hour.
If you've played the new World of Darkness you have a pretty good idea how it works. If you've played Exalted 2E or Shadowrun 4E you know exactly how it works. Roll a number of dice equal to your attribute plus skill, and count successes. There are a few powers and tricks of course, but that's all you really need to know to get started. Once the players really get into it and learn to use the stunting system the game gets very good, very fast.
This is definitely going to be a welcome addition to my personal collection, and may well take the place of my GURPS game before we really get it started. We'll see.
Whether or not it gets the nomination will of course depend on whether or not White Wolf enters it, and of course what else gets entered in its categories, but I think it makes for a strong contender.